Endocrine Abstracts

Introduction: Endocrinopathies are one of the most common autoimmune adverse events (AIAEs) causing severe toxic complications during the use of checkpoint inhibitor therapy (CPI).Clinical Case: A patient with complaints of hyperpigmentation of the skin of the back in August 2022 an excisional biopsy was performed and pigmented epithelioid cell melanoma with tumor growth along the resection margin was verified. In December 2022, CT revealed metastases in...

Introduction: According to published data, pregnancy-associated osteoporosis is a rare disease, the pathophysiology of which is currently not fully explored.Сlinical case: In 2014, a 27 year-old patient B. after the first childbirth, pain appeared in the lumbosacral spine, for which a course of physical therapy was carried out with a short-term positive effect. In 2016 after the second childbirth, pains increased; according to the results of further ...

Introduction: The occurrence of autoimmune adverse events is a frequent complication of oncoimmunotherapy with antibody drugs to PD-1.Clinical Case: At the age of 33, the patient was diagnosed with melanoma, which was surgically removed. After 3 years, there was a progression with the appearance of liver metastases which were embolized with further initiation of oncoimmunotherapy with nivolumab. As a complication of this treatment the patient developed a...

Introduction: Corticotropinomas constitute up to 45% of aggressive pituitary tumors, which characterized by rapid and invasive growth, a high Ki-67 index, resistance to conventional treatments and recurrence in 15-20% of the cases. Progression of corticotroph tumor after bilateral adrenalectomy or Nelson’s syndrome is a frequent severe complication and may present with aggressive tumor behavior.Clinical case: A Cushing disease was diagnosed in a wom...

Introduction: According to statistical data, the combination of chronic adrenal insufficiency and diabetes mellitus is the rarest among patients with autoimmune polyglandular syndrome type 2 (APS-2).Clinical Case: In 2017, a 32-year-old patient B. with excess body weight manifested type 2 diabetes mellitus with typical clinical symptoms of carbohydrate metabolism disorder. Metformin and gliclazide were recommended. After a viral pneumonia episode with ho...

Introduction: Statistical data show that in the etiological structure of ACTH-ectopic syndrome pheochromocytoma occupies one of the last places in terms of frequency of occurrence (from 2.8 to 5.6%) Its manifestations such as adrenal mass with ACTH-dependent hypercortisolism lead to significant difficulties in establishing the correct diagnosis.Clinical Case: A patient with clinical manifestations of hypercortisolism underwent laboratory testing in Octob...